High surface-to-volume ratios and penetration distances make lab-on-a-chip devices favourable for photochemistry applications.
In collaboration with Dr Theoni Georgiou at Imperial College London, we have performed photopolymerisation in droplet microfluidics to generate amphiphilic hydrogels as drug delivery vesciles.
In a project with Prof. Vesco Paunov, we have developed a flow cell onto which cyanobacteria were immobilised and maintained and achieved efficient hydrogen generation under illumination.
In collaboration with Prof. Ross Boyle, we have utilised photochemistry for the controlled generation of reactive oxygen species (ROS) by immobilisation of photosensitisers such as porphyrins on the channel walls and studied the effect on chemical oxidation reactions and biological cells.
Selected References
- B. Lu, M.D. Tarn, N. Pamme, T.K. Georgiou, Fabrication of Tailorable pH Responsive Cationic Amphiphilic Microgels on a Microfluidic Device for Drug Release, Journal of Polymer Science Part A: Polymer Chemistry, 2017, doi: 10.1002/pola.28860
- B. Lu, M.D. Tarn, N. Pamme, T.K. Georgiou, Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release, Journal of Materials Chemistry B, 2016, doi: 10.1039/C5TB02378E.
- B. Lu, M.D. Tarn, N. Pamme, T.K. Georgiou, Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release, Journal of Materials Chemistry B, 2015, 3, 4524 – 4529. doi: 10.1039/C5TB00222B
- A.K. Das, M.M.N. Esfahani, O.D. Velev, N. Pamme, V.N. Paunov, Artificial leaf device for hydrogen generation from immobilised C. reinhardtii microalgae, Journal of Materials Chemistry A, 2015, 3, 20698-20707. doi: 10.1039/C5TA07112G
- E.K Lumley, C.E. Dyer, N. Pamme, R.W. Boyle, Comparison of photo-oxidation reactions in batch and a new photosensitiser-immobilised microfluidic device, Organic Letters, 2012, 14, 5724-5727. doi: 10.1021/ol3023424
Nicole Pamme - Research Group 